课题组简介：

本课题组是“浙江省药用植物种质改良与质量控制技术重点实验室”等省市平台的核心团队，主要从事药用植物疗效品质形成的环境调控机制等方面的研究工作。近年来，重点以杭白菊、银杏、长春花等为材料解析紫外光（UV-B）等逆境因子诱导活性组分积累的分子机制，旨在阐明逆境胁迫促进药用植物品质形成（优质药材道地性形成）的信号转导机制，并以此为基础研制开发促进药用植物活性组分积累的新型分子逆境仿生调控技术，为解决制约优质药材生产的瓶颈问题、推动产业创新升级提供技术支撑。同时开展杭白菊、银杏、长春花等药用植物活性组分生物合成途径解析与关键靶点基因的调控机制解析等研究工作。

课题组成员主持研究国家自然科学基金项目9项、其它省部级项目十余项。揭示了CmUVR8等信号通路在介导UV-B等逆境因子诱导药用植物活性组分合成中的作用，解析了以MT等为关键节点调控逆境胁迫促进杭白菊活性组分积累的信号机制，建立以PC-410为靶点在不依赖逆境的情况下促进药用植物疗效品质形成的分子逆境仿生调控新技术，在药用植物资源学研究领域形成了明显的特色和优势。研究成果获得浙江省科技进步奖和省高校科技成果一等奖。在“Industrial Crops and Products”、 “Plant Cell & Environment”、 “Plant Physiology”以及“中国科学”等国内外本学科主流刊物发表相关研究论文70余篇。

课题组照片：

课题组负责人：杨燕君

课题组成员

教师：倪君、郝娟

学生：柳洁、易太垚、厉瑶、李梦圆、张宁、詹洋、丁可欣、韩怡蝶、郑黎君、刘文荣、舒小龙、龚嬿琪、夏方洁、郑欣雅、周雪晴

主要研究方向

        1. 药用植物品质形成的环境调控机制

        2. 促进药用植物活性组分积累的分子逆境仿生调控技术

        3. 杭白菊、长春花次生代谢产物合成调控

        4. 银杏黄酮合成调控机制

代表性成果：

1. Gong Y, Ding K, Zhan Y, Zhang N, Miao Z, Miao Q, Ding W, Xu M, Ni J (2025). GbbHLH65 broadly regulates flavonoid biosynthesis structural genes in Ginkgo biloba. Industrial Crops and Products 237: 122169.

2. Yang Y, Liu J, Yi T, Li Y, Li M, Liu H, Zheng L, Chen Z, Hao J, Xu M, Shen C (2023). Integrated mRNA and miRNA omics reveal the regulatory role of UV-B radiation in active ingredient biosynthesis of Chrysanthemum morifolium Ramat. Industrial Crops and Products, 197: 116657.

3. Hao Juan, Zheng Lijun, Han Yidie, et al. Genome wide identification and expression analysis of TCP family genes in Catharanthus roseus (2023), Frontiers in Plant Science, 14: 1161534.

4. Xiaori Z, Xueshuang L, Wanting L, Ruoyun M, Yue Z, Huizhong W, Lilin W, Yanjun Y, Chenjia S (2024) . Cell type specific regulation of phenolic acid and flavonoid metabolism in Taxus mairei leaves. Industrial Crops and Products, 219: 118975.

5. Zhang N, Zhan Y, Ding K, Wang L, Qi P, Ding W, Xu M, Ni J (2023). Overexpression of the Ginkgo biloba dihydroflavonol 4-reductase gene GbDFR6 results in the self-incompatibility-like phenotypes in transgenic tobacco. Plant Signaling & Behavior 18: 2163339.

6. Hao J, Lou P, Han Y, Zheng L, Lu J, Chen Z, Ni J, Yang Y, Xu M (2022). Ultraviolet-B irradiation increases antioxidant capacity of pakchoi (Brassica rapa L.) by inducing flavonoid biosynthesis. Plants (Basel) 11(6): 766.

7. Ni J, Zhang N, Zhan Y, Ding K, Qi P, Wang X, Ding W, Xu M (2022).. Transgenic tobacco plant overexpressing ginkgo dihydroflavonol 4-reductase gene GbDFR6 exhibits multiple developmental defects. Frontiers in Plant Science 13: 1066736.

8. Yang Y, Guo J, Cheng J, Jiang Z, Xu N, An X, Chen Z, Hao J, Yang S, Xu Z, Shen C, Xu M (2020). Identification of UV-B radiation responsive microRNAs and their target genes in chrysanthemum (Chrysanthemum morifolium Ramat) using high-throughput sequencing. Industrial Crops and Products, 151: 112484.

9. Hao J, Lou P, Han Y, Chen Z, Chen J, Ni J, Yang Y, Jiang Z, Xu M (2021). GrTCP11, a cotton TCP transcription factor, inhibits root hair elongation by down-regulating jasmonic acid pathway in Arabidopsis thaliana. Frontiers in Plant Science 12: 769675.

10. Yang Y, Yang X, Guo J, Jiang Z, Chen Z, Hao J, Li J, Luo X, Jin W, Wu Y, Shi X, Xu M (2018). UV RESISTANCE LOCUS 8 from Chrysanthemum morifolium Ramat (CmUVR8) plays important roles in UV-B signal transduction and UV-B-induced accumulation of flavonoid, Frontiers in Plant Science 9: 955.